Triple Negative Breast Cancer

Science

Breast cancer accounts for 18% of all cancers in women, making it the foremost cause of cancer-related deaths in women. The prevalence rates for breast cancer in seven major markets (France, Germany, Italy, Spain, UK, US and Japan) grew to over 2.14 million in 2018.

Breast cancer is the second highest cause of death in women. Currently, routine mammography is the most routinely used method for the early detection of breast cancer. Therefore, early diagnosis and treatment of breast cancer could play a monumental role in reducing deaths. Most of the drugs available for the treatment of breast cancers, target either the endocrine (estrogen; ER) or growth factor (ErbB-1, ErbB-2 [human epidermal growth factor receptor 2; HER2], ErbB-3 and ErbB-4) receptors for therapy.  However, Triple-Negative Breast Cancer lack all these receptors. It is the most aggressive type of breast cancer with incidence rate of 15%-20%, poor survival and high recurrence rates. In addition to the lack of ER/PR and HER2 receptors, complex heterogeneity and ethnic disparity associated with the manifestation of TNBC further complicates its treatment options, limiting it to radiation and/or chemotherapy, in combination with surgery.

Although there has been encouraging progress made for the treatment of Estrogen/Progesterone receptor (ER/PR) and HER 2 positive breast cancers, there is no targeted therapy currently available in the market for Triple Negative Breast Cancer. This has created a dire need to identify molecular targets that are receptor independent, to develop effective target-based therapies for Triple Negative Breast Cancer. Additionally, cancer cells find roundabouts thereby developing resistance to existent therapies.  Therefore, a radically different approach for the treatment of Triple Negative Breast Cancer is imperative, one that identifies molecular targets that are receptor independent and directly targeting the cell proliferation machinery of the cancer cells.

We have identified a unique biomarker for Triple Negative Breast Cancer that is:

  • Endocrine and growth receptor independent.
  • Directly involved in all stages of Cell Proliferation; including DNA replication, Mitosis & Cytokinesis.
  • A biomarker for all sub-types of breast cancer as well as other gynecological cancers.

Inhibition of this biomarker selectively kills cancer cells by necroptosis. Hence, this biomarker offers a dual benefit of developing therapeutics as well as companion diagnostic kits for Triple negative Breast Cancer.